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National Immunization Survey (NIS)


The National Immunization Survey (NIS) is a continuing nationwide telephone sample survey to monitor vaccination coverage rates among children 19-35 months of age and among teenagers 13-17 years of age.


Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases and National Center for Health Statistics (CDC/NCIRD and CDC/NCHS)

Data Years Available

1994-present; data collection began for Varicella in July 1996; for PCV in July 2001; data collection for teenagers began in 2006.




Telephone interviews of households with age-eligible children, followed by a mail survey of children's vaccination providers.

Selected Content

Data collected include vaccination status and date of vaccination for selected vaccines, demographic characteristics, and geographic area of residence.

Population covered

Children aged 19-35 months and teenagers aged 13-17 years in the U.S. civilian noninstitutionalized population.


NHIs is a nationwide telephone sample survey of households with age-eligible children and teenagers. NIS uses a two-phase sample design. First, a random-digit-dialing sample of telephone numbers is drawn. When households with age-eligible children are contacted, the interviewer collects information on the vaccinations received by all age-eligible children and obtains permission to contact the children's vaccination provider. In the second phase, identified providers are sent vaccination history questionnaires by mail. Providers' responses are compared with information obtained from households to provide a more accurate estimate of vaccination coverage levels. Final estimates are adjusted for households without telephones and for nonresponse.

Response rate and sample size

In 2007, vaccination data were collected from providers for 17,017 children 19-35 months of age. The overall interview response rate was 65%. Vaccination information from providers was obtained for 69% of all children who were eligible for provider follow-up. In 2009, the household response rate§ was 58.0%; a total of 20,399 adolescents with provider-verified vaccination records are included in this report, representing 57.2% of all adolescents with completed household interviews. A total of 20,066 adolescents (10,445 males and 9,621 females) are included in the national estimates.

Interpretation Issues



National Center for Health Statistics. Health United States 2009: With Special Feature on Medical Technology. Hyattsville, Maryland. 2010; pp 468-469.